Leukotriene A4 Hydrolase



Leukotriene A4 Hydrolase (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism. The images at the left and at the right correspond to one representative LTA4H, i.e. the crystal structure of yeast Leukotriene A4 Hydrolase (2xpz).

LTA4H
1xpy, 2xpz – yLTA4H – yeast

1sqm, 1gw6, 1h19 - hLTA4H (mutant) - human

LTA4H + inhibitor
2xq0 – yLTA4H+bestatin

3fh5, 3fh7, 3fh8, 3fhe, 3ful, 3fum, 3fun - hLTA4H+pyrrolidine inhibitor 1hs6 - hLTA4H+bestatin

3ftz, 3ftv, 3ftw, 3ftx, 3fui - hLTA4H+aniline derivative

3fts, 3ftu - hLTA4H+resveratrol derivative

3fty, 3fu0 - hLTA4H+pyridine derivative

3fu3, 3fu5, 3fu6, 3fud - hLTA4H+thio derivative

3fue, 3fuf, 3fuh - hLTA4H+bestatin+indole derivative

3fuj, 3fuk - hLTA4H+indole derivative

3b7r, 3cho, 3chp, 3chq, 3chr, 3chs, 2r59 - hLTA4H+inhibitor

3b7u - hLTA4H+kelatorphan

2vj8 - hLTA4H+hydroxamic acid

3b7s, 3b7t - hLTA4H (mutant)+tripeptide